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CD41 antibody [MWReg30] (FITC)

Cat. No. GTX76010

Reference 17

Host

 Rat

Clonality

 Monoclonal

Clone Name

 MWReg30

Isotype

 IgG1

Application

 FACS, IHC

Reactivity

 Mouse
Package
100 μg ($409)
See all CD41 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Neat-1/10
IHC Assay dependent

Note :

FACS
Use 10μl of the suggested working dilution to label 106 cells in 100μl.
Not tested in other applications.

Calculated MW

113 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Protect from light.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Purified murine platelets.

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Fluorescein isothiocyanate (FITC)

RRID

AB_378502

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

integrin alpha 2b , AI172977 , CD41 , CD41B , GpIIb , alphaIIb

Cellular Localization

Membrane; Single-pass type I membrane protein

Database

Research Area

REFERENCE

Clone Reference

Schmidt SN et al. Cells 2021; 10 (12) P2Y12 Inhibition in Murine Myocarditis Results in Reduced Platelet Infiltration and Preserved Ejection Fraction.
Maier A et al. Sci Rep 2020; 10 (1):13211 Molecular magnetic resonance imaging of activated platelets allows noninvasive detection of early myocarditis in mice.
Tsujino T et al. J Funct Biomater 2019; 10 (3) Striking Differences in Platelet Distribution between Advanced-Platelet-Rich Fibrin and Concentrated Growth Factors: Effects of Silica-Containing Plastic Tubes.
Walsh TG et al. Sci Rep 2018; 8 (1):14377 Loss of the mitochondrial kinase PINK1 does not alter platelet function.
Muller J et al. Haematologica 2018; (Epub) Maternal embryonic leucine zipper kinase inhibitor OTSSP167 has preclinical activity on multiple myeloma bone disease.
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REVIEW

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Application Reference
von Elverfeldt D et al. PLoS One 2012; 7 (9):e45008 In vivo detection of activated platelets allows characterizing rupture of atherosclerotic plaques with molecular magnetic resonance imaging in mice.
Clone Reference
Schmidt SN et al. Cells 2021; 10 (12) P2Y12 Inhibition in Murine Myocarditis Results in Reduced Platelet Infiltration and Preserved Ejection Fraction.
Maier A et al. Sci Rep 2020; 10 (1):13211 Molecular magnetic resonance imaging of activated platelets allows noninvasive detection of early myocarditis in mice.
Tsujino T et al. J Funct Biomater 2019; 10 (3) Striking Differences in Platelet Distribution between Advanced-Platelet-Rich Fibrin and Concentrated Growth Factors: Effects of Silica-Containing Plastic Tubes.
Walsh TG et al. Sci Rep 2018; 8 (1):14377 Loss of the mitochondrial kinase PINK1 does not alter platelet function.
Muller J et al. Haematologica 2018; (Epub) Maternal embryonic leucine zipper kinase inhibitor OTSSP167 has preclinical activity on multiple myeloma bone disease.
Gunther F et al. Sci Rep 2017; 7 (1):14898 Dual targeting improves capture of ultrasound microbubbles towards activated platelets but yields no additional benefit for imaging of arterial thrombosis.
Miyata K et al. Sci Rep 2017; 7 (1):4059 Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation.
Ziegler M et al. Sci Rep 2016; 6:38161 Highly Sensitive Detection of Minimal Cardiac Ischemia using Positron Emission Tomography Imaging of Activated Platelets.
Heidt T et al. Sci Rep 2016; 6:25044 Molecular Imaging of Activated Platelets Allows the Detection of Pulmonary Embolism with Magnetic Resonance Imaging.
von Elverfeldt D et al. Circulation 2014; Dual Contrast Molecular Imaging Allows Noninvasive Characterization of Myocardial Ischemia/Reperfusion Injury After Coronary Vessel Occlusion in Mice by MRI.
Takagi S et al. PLoS One 2013; 8 (8):e73609 Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.
Witsch T et al. J Thromb Thrombolysis 2013; A novel hollow and perforated flexible wire allows the safe and effective local application of thrombolytic therapy in a mouse model of deep vein thrombosis.
Guenther F et al. J Thromb Haemost 2013; 11 (6):1154-62 Contrast ultrasound for the quantification of deep vein thrombosis in living mice: effects of * and P2Y12 receptor inhibition.
Weibel S et al. J Transl Med 2013; 11:106 Treatment of malignant effusion by oncolytic virotherapy in an experimental subcutaneous xenograft model of lung cancer.
Application : IHC
Reactivity : Mouse
Heidt T et al. PLoS One 2011; 6 (3):e18446 Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody.
Application : IHC
von zur Muhlen C et al. Circulation 2008; 118 (3):258-67 Magnetic resonance imaging contrast agent targeted toward activated platelets allows in vivo detection of thrombosis and monitoring of thrombolysis.
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 409