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CD41 antibody [P2]

Cat. No. GTX44204

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 P2

Isotype

 IgG1

Application

 IHC-Fr, FACS

Reactivity

 Human
Package
100 μg ($629)
See all CD41 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-Fr 1:50-1:100
FACS 2 μg

Note :

FACS
5x10⁶ platelets/test
Not tested in other applications.

Calculated MW

113 kDa. ( Note )

Product Note

Reacts with gpIIb in the intact complex with gpIIIa, but not with IIb or IIIa, separately. Inhibits plateletaggregation induced by thrombin, collagen and ADP. The molecular weight of the recognized complex is135 kDa/95 kDa.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human Platelets

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

integrin subunit alpha 2b , BDPLT16 , BDPLT2 , CD41 , CD41B , GP2B , GPIIb , GT , GTA , HPA3 , PPP1R93

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 629