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CD42b antibody [AK2] (Low Endotoxin)

Cat No. GTX00461-00

Host

Mouse

Clonality

Monoclonal

Clone Name

AK2

Isotype

IgG1

Application

WB, ICC/IF, FACS, IP, ELISA

Reactivity

Human
Package
100 μg ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ICC/IF Assay dependent
FACS Assay dependent
IP Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

72 kDa. ( Note )

Specificity/Sensitivity

This antibody recognizes CD42b (GPIb alpha).

PROPERTIES

Form

Liquid

Buffer

PBS, 0.2 μm filter sterilized.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human platelets

Purification

Protein A purified

Endotoxin

Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

BDPLT1 , BDPLT3 , BSS , CD42B , CD42balpha , DBPLT3 , GP1B , GP1BA , GPIbA , GPIbalpha , VWDP , glycoprotein Ib platelet alpha subunit , CD42b , glycoprotein Ib platelet subunit alpha

Cellular Localization

Membrane

Background

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]

Database

Research Area

REFERENCE

There are currently no references for CD42b antibody [AK2] (Low Endotoxin) (GTX00461-00). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for CD42b antibody [AK2] (Low Endotoxin) (GTX00461-00). Be the first to share your experience with this product.
SDS
PBS.pdf
Package List Price ($)
$ 319