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CD42b antibody [AK2] (PE)

Cat. No. GTX00461-08

Reference 3

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 AK2

Isotype

 IgG1

Application

 FACS

Reactivity

 Human
Package
100 test ($359)
See all CD42b products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS 10 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension
Not tested in other applications.

Product Note

This antibody recognizes CD42b (GPIb alpha).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human platelets

Purification

Purified by size-exclusion chromatography

Conjugation

Phycoerythrin (PE) Wavelength

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

BDPLT1 , BDPLT3 , BSS , CD42B , CD42balpha , DBPLT3 , GP1B , GP1BA , GPIbA , GPIbalpha , VWDP , glycoprotein Ib platelet alpha subunit , CD42b , glycoprotein Ib platelet subunit alpha

Cellular Localization

Membrane

Background

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]

Database

Research Area

REFERENCE

Clone Reference

Zilberman-Rudenko J et al. Cardiovasc Eng Technol 2018; (Epub) Effect of Pneumatic Tubing System Transport on Platelet Apheresis Units.
Tsubota Y et al. J Leukoc Biol 2014; 95 (1):191-5 Novel ex vivo culture method for human monocytes uses shear flow to prevent total loss of transendothelial diapedesis function.
Alcaide P et al. Infect Immun 2010; 78 (3):1260-8 Mucin AgC10 from Trypanosoma cruzi Interferes with L-selectin-mediated monocyte adhesion.
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 359