APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 2 μg |
|
Note :
FACS
5x10⁵ platelets/test
|
Not tested in other applications.
Product Note
The molecular weight of the recognized antigen is 160 kDa. Reacts with glycoprotein Ib on megakaryocytesand platelets. Inhibits the ristocetin-dependent binding of Von Willebrand factor to platelets and ristocetininduced platelet agglutination. Inhibits platelet aggregation induced by Type I collagen and plateletactivating factor (PAF). Immunoprecipitates the components of glycoprotein Ib complex.
PROPERTIES
Form
Liquid
Buffer
PBS, 0.1% BSA
Preservative
No preservative
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.20 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Human Washed Platelets
Purification
Protein A purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
Glycoprotein Ib Platelet Subunit Alpha , Bdplt1 , Bdplt3 , Bss , Cd42B , Cd42B-Alpha , Dbplt3 , Gp1B , Gpiba , Gpibalpha , Vwdp , Gp1Ba
Cellular Localization
Cell Membrane and Plasma membrane
Background
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]
Research Area
REFERENCE
There are currently no references for CD42b antibody [SZ2] (GTX19655). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for CD42b antibody [SZ2] (GTX19655). Be the first to share your experience with this product.
