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CD44 antibody [F10-44-2]

Cat. No. GTX04720

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 F10-44-2

Isotype

 IgG2a

Application

 WB, IHC-P, FACS, IP, Activation

Reactivity

 Human
Package
100 μg ($649)
See all CD44 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P Assay dependent
FACS Assay dependent
IP Assay dependent
Activation Assay dependent
Not tested in other applications.

Calculated MW

82 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 1 mg/mL BSA

Preservative

10 mM sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified Human T Cells

Purification

Purified IgG2a

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD44,CD44 molecule (Indian blood group),CDW44,CSPG8,ECMRIII,HCELL,HUTCHI,IN,LHR,MC56,MDU2,MDU3,MIC4,Pgp1,CD44v3,CD44 variant 3,CD44v4,CD44 variant 4,CD44v6,CD44 variant 6,CD44v7,CD44 variant 7,CD44v8,CD44 variant 8,CD44v10,CD44 variant 10

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Clone Reference

D Murray et al. Anticancer Res 2004; 24 (2A):489-94 Increased Invasion and Expression of MMP-9 in Human Colorectal Cell Lines by a CD44-dependent Mechanism
Application : Activation
K Takahashi et al. Int J Cancer 1999; 80 (3):387-95 Involvement of CD44 in matrix metalloproteinase-2 regulation in human melanoma cells
Application : WB, Activation
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Package List Price ($)
$ 649