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CD45 antibody [30-F11] (Biotin)

Cat No. GTX00456

Host Rat
Clonality Monoclonal
Clone Name 30-F11
Isotype IgG2b
Application FACS
Reactivity Mouse
Package
100 μg ($179)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
FACS ≤0.25 μg per million cells in 100 μl volume
Not tested in other applications.

Calculated MW

147 kDa. ( Note )

Specificity/Sensitivity

This antibody specifically reacts with all isoforms of CD45 and also with the alloantigens CD45.1 and CD45.2 (LCA).
PROPERTIES

Form

Liquid

Buffer

PBS pH7.2, ≤0.09% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Mouse thymus or spleen

Purification

Purified by affinity chromatography

Conjugation

Biotin

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

protein tyrosine phosphatase receptor type C,B220,CD45,CD45R,GP180,L-CA,LCA,LY5,T200

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

Database

Research Area

REFERENCE
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REVIEW
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Package List Price ($)
$ 179