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CD45RB antibody [2B11 + PD7-26]

Cat. No. GTX01637

Reference 5

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 2B11 + PD7-26

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($399)
See all CD45RB products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100-1:200

Note :

IHC-P
Pretreatment of deparaffinized tissue with heat-induced epitope retrieval or enzymatic retrieval is recommended.
Not tested in other applications.

Calculated MW

147 kDa. ( Note )

Positive Control

Tonsil or lymph node

PROPERTIES

Form

Liquid

Buffer

Tris-HCl buffer, 0.2% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

PD7/26/16: human peripheral blood lymphocytes maintained in T cell growth factor. 2B11: isolated neoplastic cells from T cell lymphoma

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

protein tyrosine phosphatase receptor type C , B220 , CD45 , CD45R , GP180 , L-CA , LCA , LY5 , T200

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

Database

Research Area

REFERENCE

Clone Reference

2015; Chronic villitis of unknown etiology and massive chronic intervillositis have similar immune cell composition
Reactivity : Human
2009; Follicular dendritic cell sarcoma of small intestine with aberrant T-cell marker expression
2006; Positive pre-transplant flow-panel reactive antibody detected after accelerated acute rejection with negative pre-transplant flow crossmatch
Application : IHC-P
Reactivity : Human
2002; A clinicopathologic and immunohistochemical analysis of melanotic neuroectodermal tumor of infancy
Reactivity : Human
1991; Antibodies marking paraffin-embedded leukocytes. Status report 1991
Application : IHC-P
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Package List Price ($)
$ 399