APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
| Assay dependent |
Not tested in other applications.
Calculated MW
Product Note
This antibody reacts with a protein determinant of CD45RB and is therefore not neuraminidase sensitive like most other anti CD45RB antibodies (including standard antibody GTX28218). The reactivity of this antibody can be blocked by a peptide including amino acids 79 - 88.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
15mM Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Human peripheral blood lymphocytes.
Purification
Protein A purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
protein tyrosine phosphatase receptor type C , B220 , CD45 , CD45R , GP180 , L-CA , LCA , LY5 , T200
Cellular Localization
Cell membrane
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Database
Research Area
DATA IMAGES
![Anti-CD45RB antibody [MEM-143] used in IHC (Paraffin sections) (IHC-P). GTX23979](/templates/default/js/lightbox/images/loading.gif "Anti-CD45RB antibody [MEM-143] used in IHC (Paraffin sections) (IHC-P). GTX23979")
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GTX23979 IHC-P Image
IHC-P analysis of human tonsil tissue using GTX23979 CD45RB antibody [MEM-143].
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REFERENCE
There are currently no references for CD45RB antibody [MEM-143] (GTX23979). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for CD45RB antibody [MEM-143] (GTX23979). Be the first to share your experience with this product.
![Anti-CD45RB antibody [MEM-143] used in IHC (Paraffin sections) (IHC-P). GTX23979](/upload/website/prouct_img/small/GTX23979/GTX23979_20191025_AP_003_180_w_23060722_808.webp "Anti-CD45RB antibody [MEM-143] used in IHC (Paraffin sections) (IHC-P). GTX23979")
![Anti-CD45RB antibody [MEM-143] used in IHC (Paraffin sections) (IHC-P). GTX23979](/upload/website/prouct_img/normal/GTX23979/GTX23979_20191025_AP_003_180_w_23060722_808.webp "Anti-CD45RB antibody [MEM-143] used in IHC (Paraffin sections) (IHC-P). GTX23979")