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CD46 antibody [MEM-258] (PE)

Anti-CD46 antibody [MEM-258] (PE) used in Flow cytometry (FACS). GTX78353

Cat. No. GTX78353

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 MEM-258

Isotype

 IgG1

Application

 FACS

Reactivity

 Human, Bovine
Package
100 test ($329)
See all CD46 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS 20 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension
Not tested in other applications.

Calculated MW

44 kDa. ( Note )

Product Note

This antibody recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

HPB-ALL human T cell line

Purification

Purified by size-exclusion chromatography

Conjugation

Phycoerythrin (PE)

RRID

AB_625636

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

AHUS2 , CD46 , CD46 molecule , MCP , MIC10 , TLX , TRA2.10

Cellular Localization

Cytoplasmic vesicle,Secretory vesicle,Acrosome inner membrane

Background

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

Database

Research Area

DATA IMAGES

Anti-CD46 antibody [MEM-258] (PE) used in Flow cytometry (FACS). GTX78353

GTX78353 FACS Image

FACS analysis of human peripheral blood using GTX78353 CD46 antibody [MEM-258] (PE).

REFERENCE

Clone Reference

Tsoukas RL et al. Cells 2022; 11 (5) A Human In Vitro Model to Study Adenoviral Receptors and Virus Cell Interactions.
Tsai YG et al. Sci Rep 2018; 8 (1):12973 Complement regulatory protein CD46 induces autophagy against oxidative stress-mediated apoptosis in normal and asthmatic airway epithelium.
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 329