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CD59 antibody [MEM-43/5]

Anti-CD59 antibody [MEM-43/5] used in Western Blot (WB). GTX29183

Cat. No. GTX29183

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 MEM-43/5

Isotype

 IgG2b

Application

 WB, IHC-P, FACS, IP

Reactivity

 Human, Mouse
Package
100 μg ($339)
See all CD59 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P Assay dependent
FACS Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

14 kDa. ( Note )

Product Note

This antibody reacts with well defined epitope (around L33) on CD59 (Protectin). The MEM-43/5 does not compete with most other CD59 antibodies.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Thymocytes and T lymphocytes

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD59 , CD59 molecule , EJ16 , EJ30 , EL32 , G344 , HRF20 , MACIF , MACIP , MEM43 , MIC11 , MIN1 , MIN2 , MIN3 , MIRL , MSK21 , p1820 , CD59 molecule (CD59 blood group) , 1F5 , 16.3A5

Cellular Localization

Cell membrane,Secreted

Background

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CD59 antibody [MEM-43/5] used in Western Blot (WB). GTX29183

GTX29183 WB Image

WB analysis of HPB-ALL cell lysate (non-reducing) using GTX29183 CD59 antibody [MEM-43/5].
Lane 1 : Original cell lysate
Lane 2 : Immunoprecipitate by GTX29182

REFERENCE

Clone Reference

Miller-Novak LK et al. J Virol 2018; (Epub) Analysis of complement-mediated lysis of SIV and SIV-infected cells reveals sex differences in vaccine-induced immune responses in Rhesus macaques.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339