GeneTex
United States (US)

CD59 antibody

GTX31524_2712_WB_20180221_18121410_828.jpg

Cat No. GTX31524

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ELISA
Reactivity Human, Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 - 2 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

14 kDa. ( Note )

Positive Control

Mouse Spleen Tissue Lysate(GTX27937)
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Rabbit polyclonal CD59 antibody was raised against a 14 amino acid peptide near the amino terminus of human CD59.The immunogen is located within the first 50 amino acids of CD59.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Cd59 Molecule (Cd59 Blood Group),16.3A5,1F5,Ej16,Ej30,El32,G344,Hrf-20,Hrf20,Mac-Ip,Macif,Mem43,Mic11,Min1,Min2,Min3,Mirl,Msk21,P18-20,Cd59

Background

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX31524_2712_WB_20180221_18121410_828.jpg

GTX31524 WB Image

WB analysis of mouse spleen tissue lysate using GTX31524 CD59 antibody.
Working concentration : 1 μg/ml

Package List Price ($)
$ 329