PBS pH7.2 (10mM NaH₂PO₄, 10mM Na₂HPO₄, 130mM NaCl), 0.1% BSA
0.02% Sodium azide
Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
200 μg/ml (Please refer to the vial label for the specific concentration.)
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Cd59 Molecule (Cd59 Blood Group) , 16.3A5 , 1F5 , Ej16 , Ej30 , El32 , G344 , Hrf-20 , Hrf20 , Mac-Ip , Macif , Mem43 , Mic11 , Min1 , Min2 , Min3 , Mirl , Msk21 , P18-20 , Cd59
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]