GeneTex
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CD6 antibody [3F7B5]

Anti-CD6 antibody [3F7B5] used in IHC (Paraffin sections) (IHC-P). GTX34535
Anti-CD6 antibody [3F7B5] used in IHC (Paraffin sections) (IHC-P). GTX34535

Cat No. GTX34535

Host Mouse
Clonality Monoclonal
Clone Name 3F7B5
Isotype IgG1
Application ICC/IF, IHC-P
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF 0.5-1ug/ml
IHC-P 0.5-1ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

72 kDa. ( Note )

Specificity/Sensitivity

CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular �scavenger receptor cysteine-rich� (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Human rheumatoid synovial T cell line ST-1

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Cd6 Molecule,Tp120,Cd6

Background

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Database

Research Area

DATA IMAGES
Anti-CD6 antibody [3F7B5] used in IHC (Paraffin sections) (IHC-P). GTX34535

GTX34535 IHC-P Image

Formalin-fixed, paraffin-embedded human Tonsil stained with CD6 Monoclonal Antibody (3F7B5).

Anti-CD6 antibody [3F7B5] used in IHC (Paraffin sections) (IHC-P). GTX34535

GTX34535 IHC-P Image

Formalin-fixed, paraffin-embedded human Tonsil stained with CD6 Monoclonal Antibody (3F7B5).

Package List Price ($)
$ 329