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CD6 antibody [C6/372]

Anti-CD6 antibody [C6/372] used in IHC (Paraffin sections) (IHC-P). GTX34536

Cat No. GTX34536

Host

Mouse

Clonality

Monoclonal

Clone Name

C6/372

Isotype

IgG1

Application

ICC/IF, IHC-P

Reactivity

Human
Package
100 μg ($429)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF 0.5-1ug/ml
IHC-P 0.5-1ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

72 kDa. ( Note )

Specificity/Sensitivity

CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular �scavenger receptor cysteine-rich� (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.

PROPERTIES

Form

Liquid

Buffer

10mM PBS with 0.05% BSA, 0.05% azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml

Antigen Species

Human

Immunogen

Human recombinant CD6 protein

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Cd6 Molecule , Tp120 , Cd6

Background

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Database

Research Area

DATA IMAGES

Anti-CD6 antibody [C6/372] used in IHC (Paraffin sections) (IHC-P). GTX34536

GTX34536 IHC-P Image

Formalin-fixed, paraffin-embedded human Tonsil stained with CD6 Monoclonal Antibody (C6/372).

REFERENCE

There are currently no references for CD6 antibody [C6/372] (GTX34536). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for CD6 antibody [C6/372] (GTX34536). Be the first to share your experience with this product.
Package List Price ($)
$ 429