GeneTex
United States (US)

CD6 antibody [MEM-98]

CD6-antibody-MEM-98__GTX29181-1_18121409_447.jpg

Cat No. GTX29181

Host Mouse
Clonality Monoclonal
Clone Name MEM-98
Isotype IgG1
Application WB, FACS, IP
Reactivity Human
APPLICATION

Application Note

For FACS: Use at an assay dependent dilution. For IP: Use at an assay dependent dilution. For WB (non-reducing conditions): Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

72 kDa. ( Note )

Specificity/Sensitivity

This antibody reacts with CD6, a 100-130 kD single chain transmembrane glycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acute lymphocytic leukemia cells.
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.4, containing 15 mM sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

CD6 antigen purified by immunoaffinity chromatography from HBP ALL cells followed by preparative SDS-PAGE of non-boiled non-reduced sample (excised piece of gel corresponding to the 100 kDa zone).

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Background

CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.

Database

Research Area

DATA IMAGES
CD6-antibody-MEM-98__GTX29181-1_18121409_447.jpg

GTX29181 FACS Image

Surface staining of human peripheral blood cells with anti-human CD6: FITC (GTX75496).

Package List Price ($)
$ 319