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CD62E antibody [ENA2]

Cat. No. GTX54506

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 ENA2

Isotype

 IgG1

Application

 ICC/IF, IHC-Fr, ELISA, Neutralizing/Inhibition

Reactivity

 Human, Baboon, Chimpanzee, Cynomolgus monkey, Rhesus Monkey
Package
50 μg ($439)
See all CD62E products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
IHC-Fr Assay dependent
ELISA Assay dependent
Neutralizing/Inhibition Assay dependent

Note :

ICC/IF
In vitro cultured cells can be fixed with 1% paraformaldehyde and kept in PBS plus azide before staining. Tissue sections are advised to be fixed for 10 min in pure acetone and followed by incubation for 10 min in chloroform.

Neutralizing/Inhibition
The antibody can be used for adhesion inhibition studies for which the antibody is most efficient and prevents adhesion of leucocytes via Fc receptors.
Not tested in other applications.

Calculated MW

67 kDa. ( Note )

Product Note

The antibody inhibits the adhesion of granulocytes both neutrophilic and eosinophilic.

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized PBS, 0.1% BSA

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

100 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Purification

Purified IgG1

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD62E,ELAM,ELAM1,ESEL,LECAM2,SELE,selectin E,E-selectin

Cellular Localization

Membrane

Background

The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 439