GeneTex

  • Country / Location Selection

United States (US)

CD63 antibody [CLBGran/12] (FITC)

Cat. No. GTX44174

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 CLBGran/12

Isotype

 IgG1

Application

 FACS

Reactivity

 Human
Package
50 test ($409)
See all CD63 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS 20 μL

Note :

FACS
10⁶ platelets/test or 10⁵ cells/test
Not tested in other applications.

Calculated MW

26 kDa. ( Note )

Product Note

The molecular weight of the recognized platelet form of CD63 is 40 to 55 kDa. CLBGran/12 reacts withmost peripheral blood cells including activated platelets, lymphoid, myeloid and endothelial cells, except forred blood cells and resting T cells. The CD63 antigen is present in many tissues and cell line PHA blasts,K562, U937, KG1a, RAJI. Both surface and cytoplasmotic reactions are reported. CLB Gran/12 has beenassigned to the CD63 cluster of differentiation at the IVth International Workshop on Human LeucocyteDifferentiation Antigens.

PROPERTIES

Form

Liquid

Buffer

10mM Sodium Phosphate, 145mM NaCl, 0.2% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human cytochrome B enriched cells.

Purification

Purified IgG

Conjugation

Fluorescein isothiocyanate (FITC)

RRID

AB_11166767

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD63 molecule , LAMP-3 , ME491 , MLA1 , OMA81H , TSPAN30

Cellular Localization

Cell membrane , Lysosome membrane

Background

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

Database

Research Area

REFERENCE

Application Reference

Theodoro TR et al. J Transl Med 2019; 17 (1) : 103 Crosstalk between tumor cells and lymphocytes modulates heparanase expression.
Submit a Reference

REVIEW

There are currently no reviews for CD63 antibody [CLBGran/12] (FITC) (GTX44174). Be the first to share your experience with this product.
Submit a Review
SDS
Sodium Azide.pdf
Package List Price ($)
$ 409