GeneTex
  • Country / Location Selection

United States (US)

CD68 antibody [C68/684]

Anti-CD68 antibody [C68/684] used in IHC (Paraffin sections) (IHC-P). GTX34544
Anti-CD68 antibody [C68/684] used in IHC (Paraffin sections) (IHC-P). GTX34544

Cat No. GTX34544

Host Mouse
Clonality Monoclonal
Clone Name C68/684
Isotype IgG1
Application ICC/IF, IHC-P
Reactivity Human, Monkey
Package
100 μg ($429)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF 0.5-1ug/ml
IHC-P 0.25-0.5ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

37 kDa. ( Note )

Specificity/Sensitivity

This antibody recognizes a glycoprotein of 110kDa, which is identified as CD68. It is important for identifying macrophages in tissue sections. It stains macrophages in a wide variety of human tissues, including Kupffer cells and macrophages in the red pulp of the spleen, in lamina propria of the gut, in lung alveoli, and in bone marrow. It reacts with myeloid precursors and peripheral blood granulocytes. It also reacts with plasmacytoid T cells, which are supposed to be of monocyte/macrophage origin. It shows strong granular cytoplasmic staining of chronic and acute myeloid leukemia and also reacts with rare cases of true histiocytic neoplasia. Lymphomas are negative or show few granules.
PROPERTIES

Form

Liquid

Buffer

10mM PBS with 0.05% BSA, 0.05% azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml

Antigen Species

Human

Immunogen

Recombinant human CD68 protein

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Cd68 Molecule , Gp110 , Lamp4 , Scard1 , Cd68

Background

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
Anti-CD68 antibody [C68/684] used in IHC (Paraffin sections) (IHC-P). GTX34544

GTX34544 IHC-P Image

Formalin-fixed, paraffin-embedded human Tonsil stained with CD68 Monoclonal Antibody (C68/684).

Anti-CD68 antibody [C68/684] used in IHC (Paraffin sections) (IHC-P). GTX34544

GTX34544 IHC-P Image

Formalin-fixed, paraffin-embedded human Histiocytoma stained with CD68 Monoclonal Antibody (C68/684).

REFERENCE
There are currently no references for CD68 antibody [C68/684] (GTX34544). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for CD68 antibody [C68/684] (GTX34544). Be the first to share your experience with this product.
Package List Price ($)
$ 429