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CD68 antibody [PG-M1]

Anti-CD68 antibody [PG-M1] used in IHC (Paraffin sections) (IHC-P). GTX73723
Anti-CD68 antibody [PG-M1] used in Immunohistochemistry (IHC). GTX73723

Cat. No. GTX73723

Reference 5

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 PG-M1

Isotype

 IgG3

Application

 ICC/IF, IHC-P, IHC

Reactivity

 Human, Mouse
Package
500 μl ($529)
See all CD68 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
IHC-P 1:10‐1:40
IHC Assay dependent
Not tested in other applications.

Calculated MW

37 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Antigen Species

Human

Immunogen

BALB/C mice were immunized with Gaucher’s cells.

Purification

Unpurified

Conjugation

Unconjugated

RRID

AB_375099

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD68 molecule , GP110 , LAMP4 , SCARD1

Background

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CD68 antibody [PG-M1] used in IHC (Paraffin sections) (IHC-P). GTX73723

GTX73723 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX73723 CD68 antibody [PG-M1].

Anti-CD68 antibody [PG-M1] used in Immunohistochemistry (IHC). GTX73723

GTX73723 IHC Image

The data was published in the journal Front Immunol in 2017. PMID: 28567040

REFERENCE

Application Reference

Y Shen et al. JCI Insight 2023; : e166540 Evidence of a Sj?gren's disease-like phenotype following COVID-19 in mice and human
Application : IHC-P
Reactivity : Mouse
Thirunavukkarasu S et al. J Clin Invest 2023; 133 (12) Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production.
Garcia-Hernandez ML et al. Front Immunol 2017; 8 : 563 A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression.
Application : IHC-P
Reactivity : Human
Hamada D et al. Arthritis Rheumatol 2016; 68 (6) : 1392-402 suppressive effects of * on tumor necrosis factor-dependent early osteoarthritic changes associated with obesity and type 2 diabetes mellitus.
Hamada D et al. Arthritis Rheumatol68 2016; (6) : 1392–1402 * suppresses tnf-dependent early osteoarthritic changes associated with obesity and type 2 diabetes.
Application : ICC/IF
Reactivity : Human
Submit a Reference

REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 529