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CD68 antibody [SPM130]

Anti-CD68 antibody [SPM130] used in IHC (Paraffin sections) (IHC-P). GTX34543

Cat. No. GTX34543

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 SPM130

Isotype

 IgG1

Application

 ICC/IF, IHC-P, FACS

Reactivity

 Human, Rabbit, Cat, Monkey
Package
100 μg ($529)
See all CD68 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF 1-2μg/ml
IHC-P 1-2μg/ml for 30 minutes at RT
FACS 1-2μg/10⁶ cells

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

37 kDa. ( Note )

Product Note

We do not recommend use of this product for Dog,Chicken,Pig samples.

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Subcellular fraction of human alveolar macrophages

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD68 , CD68 molecule , GP110 , LAMP4 , SCARD1

Cellular Localization

Cell membrane,Endosome membrane,Lysosome membrane

Background

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-CD68 antibody [SPM130] used in IHC (Paraffin sections) (IHC-P). GTX34543

GTX34543 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX34543 CD68 antibody [SPM130].

REFERENCE

Application Reference

Hwang JC et al. Sci Adv 2022; 8 (37) : eabq0897 In situ diagnosis and simultaneous treatment of cardiac diseases using a single-device platform.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 529