GeneTex
United States (US)

CD71 antibody [23D10]

Cat No. GTX10251

Host Mouse
Clonality Monoclonal
Clone Name 23D10
Isotype IgG2b
Application ELISA
Reactivity Human
APPLICATION

Application Note

ELISA: Use at an assay dependent dilution. Recommended pair antibody: GTX10251 (detection) with GTX10254 (coating). Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

85 kDa. ( Note )

Specificity/Sensitivity

This antibody reacts with human soluble transferrin receptor.
PROPERTIES

Form

Liquid

Buffer

Preservative: 0.1% Sodium Azide; Constituents: PBS. pH 7.4

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Antigen Species

Human

Immunogen

Recombinant full length protein (Human).

Purification

Protein A purified
Purity tested by electrophoresis.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

TFR, TFR1, 7037, 190010, Transferrin receptor, TFRC, CD71, P02786, TRFR

Background

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.

Database

Research Area