ELISA: Use at an assay dependent dilution. Recommended pair antibody: GTX10252 (coating) with GTX10249 (detection).ab 10253 (detection) with GTX10252 (coating). Optimal dilutions/concentrations should be determined by the end user.
This antibody reacts with human soluble transferrin receptor.
Preservative: 0.1% Sodium Azide; Constituents: PBS. pH 7.4
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Recombinant full length protein (Human).
Protein A purified
Purity tested by electrophoresis.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TFR, TFR1, 7037, 190010, Transferrin receptor, TFRC, CD71, P02786, TRFR
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.