GeneTex

  • Country / Location Selection

United States (US)

CD8 alpha antibody [OKT-8]

Cat. No. GTX14198

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 OKT-8

Isotype

 IgG2a

Application

 Depletion

Reactivity

 Human
Package
500 μg ($399)
See all CD8 alpha products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
Depletion Assay dependent

Note :

Depletion
in vivo CD8+ T cell depletion in humanized mice
Not tested in other applications.

Calculated MW

26 kDa. ( Note )

Product Note

The OKT-8 antibody does not block the binding of the anti-human CD8α antibodies RPA-T8 and HIT8a.

PROPERTIES

Form

Liquid

Buffer

0.2μm-filtered PBS (pH6.0), 0.01% Tween

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human CD8α

Purification

Protein G purified
From tissue culture supernatant

Purity

>95% (Determined by SDS-PAGE)

Endotoxin

< 0.002 EU/弮g (Determined by LAL assay)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD8,CD8A,CD8a molecule,Leu2,MAL,p32,CD8 alpha

Cellular Localization

Cell membrane,Secreted

Background

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Database

Research Area

REFERENCE

There are currently no references for CD8 alpha antibody [OKT-8] (GTX14198). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for CD8 alpha antibody [OKT-8] (GTX14198). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 399