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CD80 antibody [2D10.4]

Cat. No. GTX01487

Reference 3

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 2D10.4

Isotype

 IgG1

Application

 ICC/IF, FACS, Activation

Reactivity

 Human, Rhesus Monkey
Package
100 μg ($149)
See all CD80 products
PRODUCT

Summary

The 2D10.4 antibody reacts with human CD80, a 60 kDa glycoprotein that is a member of the Ig superfamily. CD80, also known as B7-1, is a ligand for the T cell receptors CD28 and CTLA-4 (CD152). Along with CD86, CD80 plays a major role in regulating the activation of T cells. CD80 is expressed by activated antigen presenting cells including B cells, macrophages, and dendritic cells. Activated T cells have also been reported to express CD80.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
FACS Assay dependent
Activation Assay dependent
Not tested in other applications.

Calculated MW

33 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM NaH₂PO₄, 150mM NaCl

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Purification

Purified by affinity chromatography
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD80 molecule , B7 , B7.1 , B71 , BB1 , CD28LG , CD28LG1 , CD80 , LAB7 , B7-1

Cellular Localization

Membrane

Background

The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]

Database

Research Area

REFERENCE

Clone Reference

2015; Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions.
Application : ICC/IF
Reactivity : Human
2014; Genuine Immunomodulation With dSLIM.
2005; Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates.
Application : Activation
Reactivity : Rhesus Monkey
Submit a Reference

REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 149