GeneTex
United States (US)

CD80 antibody [MEM-233]

GTX28239_CD80-antibody-MEM-233__GTX28239-1_19012723_886.jpeg

Cat No. GTX28239

Host Mouse
Clonality Monoclonal
Clone Name MEM-233
Isotype IgG1
Application FACS, IP
Reactivity Human
APPLICATION

Application Note

For FACS: Use at an assay dependent dilution. For IP: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

33 kDa. ( Note )

Specificity/Sensitivity

CD80 (B7-1)
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.4, containing 15 mM sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Fusion protein (Human).

Purification

Protein A purified
> 95% (by SDS-PAGE)

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Cd80 Molecule,B7,B7-1,B7.1,Bb1,Cd28Lg,Cd28Lg1,Lab7,Cd80

Cellular Localization

Cell Membrane

Background

CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.

Database

Research Area

DATA IMAGES
GTX28239_CD80-antibody-MEM-233__GTX28239-1_19012723_886.jpeg

GTX28239 FACS Image

Surface staining of RAJI human Burkitt lymphoma cell line with anti-human CD80: APC (GTX78330). Total viable cells were used for analysis.