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CD86 antibody [7F35]

Cat No. GTX52552

Host Mouse
Clonality Monoclonal
Clone Name 7F35
Isotype IgG1
Application WB, FACS, Neut
Reactivity Human
Package
100 μg ($329)
APPLICATION

Application Note

FC(1:50-100)|Neutralizing|WB(1:500-1000)

Calculated MW

38 kDa. ( Note )

Specificity/Sensitivity

This antibody was selected for its ability to detect human CD86 protein.
PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Human recombinant CD86 EC domian

Purification

The IgG fraction of culture supernatant was purified by Protein G affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Cd86 Molecule,B7-2,B7.2,B70,Cd28Lg2,Lab72,Cd86

Background

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

Database

Research Area

REFERENCE
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REVIEW
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SDS
PBS.pdf