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CDH16 antibody [CDH16/1532R]

Anti-CDH16 antibody [CDH16/1532R] used in IHC (Paraffin sections) (IHC-P). GTX34583
Anti-CDH16 antibody [CDH16/1532R] used in IHC (Paraffin sections) (IHC-P). GTX34583
Anti-CDH16 antibody [CDH16/1532R] used in IHC (Paraffin sections) (IHC-P). GTX34583

Cat No. GTX34583

Host Rabbit
Clonality Monoclonal
Clone Name CDH16/1532R
Isotype IgG
Application ICC/IF, IHC-P
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF 1-2ug/ml
IHC-P 0.5-1ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM Tris with 1mM EDTA buffer, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

90 kDa. ( Note )

Specificity/Sensitivity

This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Antigen Species

Human

Immunogen

Recombinant human full-length CDH16 protein

Purification

Ab purified by Protein A

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Cadherin 16,Cdh16

Background

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Database

Research Area

DATA IMAGES
Anti-CDH16 antibody [CDH16/1532R] used in IHC (Paraffin sections) (IHC-P). GTX34583

GTX34583 IHC-P Image

Formalin-fixed, paraffin-embedded Human Renal Cell Carcinoma Stained with KSP-Cadherin Recombinant Rabbit Monoclonal Antibody (CDH16/1532R)

Anti-CDH16 antibody [CDH16/1532R] used in IHC (Paraffin sections) (IHC-P). GTX34583

GTX34583 IHC-P Image

Formalin-fixed, paraffin-embedded Rat Kidney stained with KSP-Cadherin Recombinant Rabbit Monoclonal Antibody (CDH16/1532R)

Anti-CDH16 antibody [CDH16/1532R] used in IHC (Paraffin sections) (IHC-P). GTX34583

GTX34583 IHC-P Image

Formalin-fixed, paraffin-embedded Mouse Kidney Stained with KSP-Cadherin Rabbit Monoclonal Antibody (CDH16/1532R)

Package List Price ($)
$ 379