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CDK4 antibody [DCS 31.2]

Cat No. GTX75694

Host

Mouse

Clonality

Monoclonal

Clone Name

DCS 31.2

Isotype

IgG1

Application

WB, IHC-Fr, IP

Reactivity

Human, Mouse, Rat
Package
100 μg ($599)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IHC-Fr Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

34 kDa. ( Note )

Specificity/Sensitivity

This antibody does not cross react with other cdk's and does not co-precipitate the D type cyclins bound to cdk4.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.08% Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Cyclin Dependent Kinase 4 , Cmm3 , Psk-J3 , Cdk4

Background

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

There are currently no references for CDK4 antibody [DCS 31.2] (GTX75694). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for CDK4 antibody [DCS 31.2] (GTX75694). Be the first to share your experience with this product.
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 599