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CDK6 antibody [DCS 83.1]

Anti-CDK6 antibody [DCS 83.1] used in Western Blot (WB). GTX75692

Cat. No. GTX75692

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 DCS 83.1

Isotype

 IgG1

Application

 WB, IHC-Fr, IP

Reactivity

 Human
Package
50 μg ($399)
See all CDK6 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-Fr Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

37 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.08% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant cdk6 protein

Purification

Protein A purified

Conjugation

Unconjugated

RRID

AB_376969

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

cyclin dependent kinase 6 , MCPH12 , PLSTIRE

Cellular Localization

Cytoplasm , Nucleus

Background

The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]

Database

Research Area

DATA IMAGES

Anti-CDK6 antibody [DCS 83.1] used in Western Blot (WB). GTX75692

GTX75692 WB Image

WB analysis of MOLT4 cell lysate using GTX75692 CDK6 antibody [DCS 83.1].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399