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CDKN2A / p14ARF antibody

Anti-CDKN2A / p14ARF antibody used in Immunohistochemistry (IHC). GTX23642

Cat No. GTX23642

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ICC/IF, IHC-P, IHC-Fr, IHC

Reactivity

Human
Package
500 μl ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
IHC Assay dependent
Not tested in other applications.

PROPERTIES

Form

Liquid

Buffer

<0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Immunogen

Synthetic peptide corresponding to the C-terminal region of Human p14ARF.

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

ARF , CDK4I , CDKN2 , CDKN2A , CMM2 , INK4 , INK4A , MLM , MTS1 , P14 , P14ARF , P16 , P16INK4 , P16INK4A , P19 , P19ARF , TP16 , cyclin dependent kinase inhibitor 2A , p16 , p16INK4a , p14ARF , p19ARF , P14 ARF , p19 ARF

Cellular Localization

Cytoplasm,Nucleus,Nucleolus,Nucleoplasm,Mitochondrion

Background

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

Database

Research Area

DATA IMAGES

Anti-CDKN2A / p14ARF antibody used in Immunohistochemistry (IHC). GTX23642

GTX23642 IHC Image

IHC Image using GTX23642 - Detection of p12ARF by IHC in Human Cercival Cancer

REFERENCE

REVIEW

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SDS
Sodium Azide.pdf