GeneTex
  • Country / Location Selection

United States (US)

CDKN2A / p16INK4a antibody [IHC016]

Anti-CDKN2A / p16INK4a antibody [IHC016] used in IHC (Paraffin sections) (IHC-P). GTX57189

Cat No. GTX57189

Host

Mouse

Clonality

Monoclonal

Clone Name

IHC016

Isotype

IgG1

Application

IHC-P

Reactivity

Human
Package
500 μl ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 1:100-1:200

Note :

IHC-P
Heat-induced epitope retrieval (HIER) at pH 9 for 10 - 30 minutes

Not tested in other applications.

Calculated MW

17 kDa. ( Note )

Positive Control

Normal Pancreas, Normal Tonsil

PROPERTIES

Form

Liquid

Buffer

Tris buffer pH 7.3 - 7.7, 1% BSA, <0.1% Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human p16INK4A C-terminus protein protein.

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Cyclin Dependent Kinase Inhibitor 2A , Arf , Cdk4I , Cdkn2 , Cmm2 , Ink4 , Ink4A , Mlm , Mts-1 , Mts1 , P14 , P14Arf , P16 , P16-Ink4A , P16Ink4 , P16Ink4A , P19 , P19Arf , Tp16 , Cdkn2A

Background

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

Research Area

DATA IMAGES

Anti-CDKN2A / p16INK4a antibody [IHC016] used in IHC (Paraffin sections) (IHC-P). GTX57189

GTX57189 IHC-P Image

IHC-P analysis of human colon tissue using GTX57189 CDKN2A / p16INK4a antibody [IHC016]

REFERENCE

There are currently no references for CDKN2A / p16INK4a antibody [IHC016] (GTX57189). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for CDKN2A / p16INK4a antibody [IHC016] (GTX57189). Be the first to share your experience with this product.
SDS
Sodium Azide.pdf
Package List Price ($)
$ 319