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CDX2 antibody [CDX2/1690]

Anti-CDX2 antibody [CDX2/1690] used in IHC (Paraffin sections) (IHC-P). GTX34585
Anti-CDX2 antibody [CDX2/1690] used in IHC (Paraffin sections) (IHC-P). GTX34585

Cat No. GTX34585

Host

Mouse

Clonality

Monoclonal

Clone Name

CDX2/1690

Isotype

IgG2a

Application

ICC/IF, IHC-P

Reactivity

Human
Package
100 μg ($429)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF 1-2ug/ml
IHC-P 0.5-1ug/ml for 30 minutes at RT

Note :

IHC-P
Boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes

Not tested in other applications.

Calculated MW

34 kDa. ( Note )

Specificity/Sensitivity

The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.

PROPERTIES

Form

Liquid

Buffer

10mM PBS with 0.05% BSA, 0.05% azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml

Antigen Species

Human

Immunogen

Recombinant human CDX2 protein fragment (aa150-249) (exact sequence is proprietary)

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Caudal Type Homeobox 2 , Cdx-3 , Cdx2/As , Cdx3 , Cdx2

Background

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]

Database

Research Area

DATA IMAGES

Anti-CDX2 antibody [CDX2/1690] used in IHC (Paraffin sections) (IHC-P). GTX34585

GTX34585 IHC-P Image

Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with CDX2 Mouse Monoclonal Antibody (CDX2/1690).

Anti-CDX2 antibody [CDX2/1690] used in IHC (Paraffin sections) (IHC-P). GTX34585

GTX34585 IHC-P Image

Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with CDX2 Mouse Monoclonal Antibody (CDX2/1690).

REFERENCE

There are currently no references for CDX2 antibody [CDX2/1690] (GTX34585). Be the first to share your publications with this product.

REVIEW

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Package List Price ($)
$ 429