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CFTR antibody [SPM176]

Anti-CFTR antibody [SPM176] used in IHC (Paraffin sections) (IHC-P). GTX34588

Cat No. GTX34588

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 SPM176

Isotype

 IgG2a

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Mouse
Package
100 μg ($339)
See all CFTR products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1-2μg/ml
ICC/IF 1-2μg/ml
IHC-P 1-2μg/ml for 30 minutes at RT

Note :

IHC-P
Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10mM Tris buffer with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

168 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA, 0.05% sodium azide (Please contact us for PBS only format)

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml

Antigen Species

Human

Immunogen

Recombinant human CFTR fragment

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

ABC35,ABCC7,CF,CFTR,CFTR/MRP,MRP7,TNRCFTR,cystic fibrosis transmembrane conductance regulator,dJ760C5.1,CF transmembrane conductance regulator

Cellular Localization

Apical cell membrane,Early endosome membrane,Cell membrane,Recycling endosome membrane,Endoplasmic reticulum membrane

Background

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. The encoded protein functions as a chloride channel, making it unique among members of this protein family, and controls ion and water secretion and absorption in epithelial tissues. Channel activation is mediated by cycles of regulatory domain phosphorylation, ATP-binding by the nucleotide-binding domains, and ATP hydrolysis. Mutations in this gene cause cystic fibrosis, the most common lethal genetic disorder in populations of Northern European descent. The most frequently occurring mutation in cystic fibrosis, DeltaF508, results in impaired folding and trafficking of the encoded protein. Multiple pseudogenes have been identified in the human genome. [provided by RefSeq, Aug 2017]

Database

Research Area

DATA IMAGES

Anti-CFTR antibody [SPM176] used in IHC (Paraffin sections) (IHC-P). GTX34588

GTX34588 IHC-P Image

IHC-P analysis of human pancreas tissue using GTX34588 CFTR antibody [SPM176].

REFERENCE

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REVIEW

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Package List Price ($)
$ 339