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CGRP antibody [4901]

Anti-CGRP antibody [4901] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX82726

Cat. No. GTX82726

Reference 9

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 4901

Isotype

 IgG2a

Application

 WB, ICC/IF, IHC-Fr, ELISA, IHC, Neutralizing/Inhibition, RIA

Reactivity

 Human, Mouse, Rat, Dog
Package
100 μl ($499)
See all CGRP products

APPLICATION

Application Note

Optimal working dilutions should be determined experimentally by the end user.

Calculated MW

15 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM HEPES, 150mM NaCl, 0.01% BSA, 50% Glycerol

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Purified rat alpha-CGRP

Purification

Protein G purified

Conjugation

Unconjugated

RRID

AB_11173100

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Calcitonin-Related Polypeptide Alpha , Cal6 , Cgrp , Cal1 , Calc , Ratcal6 , Calcitonin , Calca

Background

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

Research Area

DATA IMAGES

Anti-CGRP antibody [4901] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX82726

GTX82726 ICC/IF Image

Immunostaining of CGRP (red) in cryopreserved DRG neurons grown on coverslips. 40xmag. Green staining is PGP9.5. Yellow staining is the colocalization of CGRP and PGP9.5.

REFERENCE

Application Reference

Li L et al. Brain Behav Immun 2021; 98 : 265-282 KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats.
Application : IHC-Fr
Reactivity : Rat

Clone Reference

J Meng et al. J Allergy Clin Immunol 2018; 141 (5):1677-1689.e8 New mechanism underlying IL-31–induced atopic dermatitis
Application : ICC/IF
Reactivity : Mouse
Hashimoto M et al. Front Neural Circuits 2018; 12 (6) Anatomical Evidence for a Direct Projection from Purkinje Cells in the Mouse Cerebellar Vermis to Medial Parabrachial Nucleus
Application : IHC-Fr
Reactivity : Mouse
SL Holtz et al. J Comp Neurol. 2015; 523 (1):139–161 Morphology and Connectivity of Parabrachial and Cortical Inputs to Gustatory Thalamus in Rats
Application : RIA
B Waber-Wenger et al. Histochem Cell Biol 2014; 142 (4):433-47 Sensory innervation of the dorsal longitudinal ligament and the meninges in the lumbar spine of the dog
Reactivity : Dog
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REVIEW

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Application Reference
Li L et al. Brain Behav Immun 2021; 98:265-282 KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats.
Application : IHC-Fr
Reactivity : Rat
Fang Z et al. PLoS One 2013; 8 (8):e72738 Effect of CGRP-adenoviral vector transduction on the osteoblastic differentiation of rat adipose-derived stem cells.
Application : WB
Reactivity : Human
Clone Reference
J Meng et al. J Allergy Clin Immunol 2018; 141 (5):1677-1689.e8 New mechanism underlying IL-31–induced atopic dermatitis
Application : ICC/IF
Reactivity : Mouse
Hashimoto M et al. Front Neural Circuits 2018; 12 (6) Anatomical Evidence for a Direct Projection from Purkinje Cells in the Mouse Cerebellar Vermis to Medial Parabrachial Nucleus
Application : IHC-Fr
Reactivity : Mouse
SL Holtz et al. J Comp Neurol. 2015; 523 (1):139–161 Morphology and Connectivity of Parabrachial and Cortical Inputs to Gustatory Thalamus in Rats
Application : RIA
B Waber-Wenger et al. Histochem Cell Biol 2014; 142 (4):433-47 Sensory innervation of the dorsal longitudinal ligament and the meninges in the lumbar spine of the dog
Reactivity : Dog
KE Bowler et al. Neuroscience 2013; 228:271-82 Evidence for anti-inflammatory and putative analgesic effects of a monoclonal antibody to calcitonin gene-related peptide
Application : Neutralizing/Inhibition
J Zeller et al. Br J Pharmacol 2008; 155 (7):1093-103 CGRP function-blocking antibodies inhibit neurogenic vasodilatation without affecting heart rate or arterial blood pressure in the rat
Application : ELISA
HC Wong et al. Hybridoma 1993; 12 (1):93-106 Monoclonal Antibody to Rat a-CGRP: Production, Characterization, and In Vivo Immunoneutralization Activity
Application : IHC
Reactivity : Dog
SDS
Glycerol.pdf
Package List Price ($)
$ 499