CHCHD2 antibody

Cat. No. GTX17498

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P, FACS, ELISA
Reactivity	Human
Package	400 μl ($399)

See all CHCHD2 products

Datasheet
Document

View product citations for antibody GTX17498 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	Assay dependent
IHC-P	Assay dependent
FACS	Assay dependent
ELISA	Assay dependent

Not tested in other applications.

Calculated MW

16 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A KLH conjugated synthetic peptide between 74-103 amino acids from the Central region of human CHCHD2.

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

coiled-coil-helix-coiled-coil-helix domain containing 2 , C7orf17 , MIX17B , MNRR1 , NS2TP , PARK22

Cellular Localization

Nucleus,Mitochondrion

Background

The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Database

Gene ID: 51142 CHCHD2
UniProt: Q9Y6H1 CHCHD2

Research Area

DATA IMAGES

GTX17498 FACS Image

FACS analysis of WiDr cells using GTX17498 CHCHD2 antibody.
Green : primary antibody
Blue : negative control

GTX17498 WB Image

WB analysis of WiDr cell line lysates (35ug/lane) using GTX17498 CHCHD2 antibody.

GTX17498 IHC-P Image

IHC-P analysis of human colon carcinoma using GTX17498 CHCHD2 antibody.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf

Package

List Price ($)

400 μl

$ 399

Qty