GeneTex
United States (US)

CHX10 antibody

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Cat No. GTX16142

Host Sheep
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human, Mouse, Rat, Bovine
APPLICATION

Application Note

WB: Use at a concentration of 0.5 - 1 μg/ml. Detects a band of approximately 46 kDa in mouse and rat retinal tissue lysates. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

39 kDa. ( Note )

Positive Control

Rat or mouse retinal tissue lysate
PROPERTIES

Form

Liquid

Buffer

Preservative: 0.08% Sodium Azide; Constituents: PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment, corresponding to N terminal amino acids 1-131 of Human CHX10.

Purification

IgG fraction
This antibody is provided as a 0.2 μm sterile filtered solution.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Visual System Homeobox 2,Chx10,Hox10,Mcop2,Mcopcb3,Ret1,Vsx2

Cellular Localization

Nuclear

Background

CHX10 is a 40kDa homeodomain protein of the paired-like class that is essential for development of the mammalian eye. Mutations in CHX10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina CHX10 is expressed in retinal progenitors, while in the mature retina, CHX10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the CHX10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. CHX10 is also expressed in the developing brainstem, thalamus, and spinal cord.

Database

Research Area

DATA IMAGES
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GTX16142 WB Image

CHX10 antibody

Package List Price ($)
$ 329