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CLCN3 antibody, C-term

Anti-CLCN3 antibody, C-term used in Western Blot (WB). GTX47617
Anti-CLCN3 antibody, C-term used in IHC (Paraffin sections) (IHC-P). GTX47617
Anti-CLCN3 antibody, C-term used in Western Blot (WB). GTX47617

Cat. No. GTX47617

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μg ($399)
See all CLCN3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.2-2.5 ug/ml
IHC-P 2-10 ug/ml
Not tested in other applications.

Calculated MW

91 kDa. ( Note )

Positive Control

293T , HepG2

PROPERTIES

Form

Liquid

Buffer

PBS, 2% Sucrose

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a C-terminal region of Human CLCN3

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

chloride voltage-gated channel 3 , CLC3 , ClC-3

Background

This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Database

Research Area

DATA IMAGES

Anti-CLCN3 antibody, C-term used in Western Blot (WB). GTX47617

GTX47617 WB Image

WB analysis of 293T cells using GTX47617 CLCN3 antibody at 1.0μg/ml.

Anti-CLCN3 antibody, C-term used in IHC (Paraffin sections) (IHC-P). GTX47617

GTX47617 IHC-P Image

IHC-P analysis of human brain tissue using GTX47617 CLCN3 antibody at 4.0-8.0μg/ml.

Anti-CLCN3 antibody, C-term used in Western Blot (WB). GTX47617

GTX47617 WB Image

WB analysis of HepG2 cells using GTX47617 CLCN3 antibody at 1.25μg/ml.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399