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CNTF antibody [AS23]

Cat. No. GTX17284

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 AS23

Isotype

 IgG1

Application

 WB, IP, ELISA

Reactivity

 Human
Package
100 μg ($399)
See all CNTF products

APPLICATION

Application Note

ELISA: This antibody has been used as a coating antibody at 10 ug/ml in a two site ELISA with PS2-B. Typically the ELISA has a working range of 0-20000 pg/ml and a sensitivity of 10 pg/ml when used with biotin conjugated CNTF antibody. Recommended sample volumes are 25-200 μl. Recovery of hCNTF in human plasma is typically > 85 in the ELISA. IP: This antibody has been used to immunoprecipitate >90% hCNTF in solution using a double-antibody method. WB: Use at a concentration of 1 - 5 μg/ml. Predicted molecular weight: 24 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

23 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.08% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Unfortunately, this information is considered to be commercially sensitive

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ciliary neurotrophic factor , HCNTF

Cellular Localization

Cytoplasm

Background

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]

Database

Research Area

REFERENCE

There are currently no references for CNTF antibody [AS23] (GTX17284). Be the first to share your publications with this product.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399