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COL17A1 antibody [GT1273]

Recombinant antibody
Anti-COL17A1 antibody [GT1273] used in Western Blot (WB). GTX03185
Anti-COL17A1 antibody [GT1273] used in IHC (Paraffin sections) (IHC-P). GTX03185

Cat. No. GTX03185

Host

 Rabbit

Clonality

 Monoclonal

Clone Name

 GT1273

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μl ($439)
See all COL17A1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

150 kDa. ( Note )

Observed MW

120-180 kDa. The observed M.W. is based on the following publication. PMID: 26967482

PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.05% BSA, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthesized peptide derived from human Collagen XVII.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

collagen type XVII alpha 1 chain , BA16H23.2 , BP180 , BPA-2 , BPAG2 , ERED , LAD-1

Background

This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-COL17A1 antibody [GT1273] used in Western Blot (WB). GTX03185

GTX03185 WB Image

Various whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with COL17A1 antibody [GT1273] (GTX03185) diluted at 1:10000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
The observed M.W. is based on the publication: PMID: 26967482

Anti-COL17A1 antibody [GT1273] used in IHC (Paraffin sections) (IHC-P). GTX03185

GTX03185 IHC-P Image

IHC-P analysis of human esophageal cancer section using GTX03185 COL17A1 antibody [GT1273].
Dilution : 1:100

REFERENCE

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REVIEW

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Package List Price ($)
$ 439