GeneTex
United States (US)

COMP antibody

Cat No. GTX14515

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P, IHC
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

WB: Use at a dilution of 1:1000. Predicted molecular weight: 84 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

83 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Whole antiserum

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

whole antiserum

Antigen Species

Rat

Immunogen

Recombinant rat COMP (Type III repeats + C terminal region).

Purification

Unpurified
From polyclonal serum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Cartilage Oligomeric Matrix Protein,Edm1,Epd1,Med,Psach,Thbs5,Tsp5,Comp

Cellular Localization

Secreted

Background

COMP is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF like and calcium binding (thrombospondin like) domains. Oligomerization results from formation of a five stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).

Database

Research Area

REFERENCE
Application Reference
Package List Price ($)
$ 449