Phosphate-buffered saline, pH 7.4, containing 1% BSA and sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Batch dependent (Please refer to the vial label for the specific concentration.)
The immunogen corresponding to a region within amino acids 513 and 604 of rat COX-2 (Uniprot: P35355).
Immunogen affinity purified
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Prostaglandin-Endoperoxide Synthase 2,Cox-2,Cox2,Ptgs2
Cytoplasmic and membrane
COX2 (Cyclooxygenase 2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.