GeneTex
United States (US)

COX2 antibody

COX2-antibody-GTX15191-IHC-1_18121409_522.jpg

Cat No. GTX15191

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application IHC-P
Reactivity Human, Mouse
APPLICATION

Application Note

For IHC-P: Use at a dilution of 1:100 for 10 min at RT. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

69 kDa. ( Note )

Positive Control

Lung carcinoma and colon carcinoma
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.4, containing 1% BSA and sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

The immunogen corresponding to a region within amino acids 513 and 604 of rat COX-2 (Uniprot: P35355).

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Prostaglandin-Endoperoxide Synthase 2,Cox-2,Cox2,Ptgs2

Cellular Localization

Cytoplasmic and membrane

Background

COX2 (Cyclooxygenase 2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.

Database

Research Area

DATA IMAGES
COX2-antibody-GTX15191-IHC-1_18121409_522.jpg

GTX15191 IHC-P Image

GTX15191 staining COX2 / Cyclooxygenase in human breast carcinoma by Immunohistochemistry (FFPE-sections)

REFERENCE
Package List Price ($)
$ 319