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COX2 antibody

Orthogonal
Anti-COX2 antibody used in Western Blot (WB). GTX60935
Anti-COX2 antibody used in IHC (Paraffin sections) (IHC-P). GTX60935
Anti-COX2 antibody used in Western Blot (WB). GTX60935

Cat. No. GTX60935

Reference 4

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all COX2 products

APPLICATION

Application Note

WB: 1:500-1:1000, IHC: 1:50-1:200, IF: 1:50-1:200

Calculated MW

69 kDa. ( Note )

Product Note

Cox2 (T594) pAb detects endogenous levels of Cox2 protein.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide, corresponding to amino acids C-terminus of Human Cox-2.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugation

Unconjugated

RRID

AB_2888010

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

prostaglandin-endoperoxide synthase 2 , COX-2 , COX2 , GRIPGHS , PGG/HS , PGHS-2 , PHS-2 , hCox-2

Background

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]

Database

Research Area

DATA IMAGES

Anti-COX2 antibody used in Western Blot (WB). GTX60935

GTX60935 WB Image

Western blot (WB) analysis of Cox-2 pAb at 1:500 dilution. Lane1:Hela whole cell lysate treated with LPS. Lane2:Jurkat whole cell lysate treated with LPS. Lane3:Raw264.7 whole cell lysate treated with LPS. Lane3:Rat lung tissue lysate

Anti-COX2 antibody used in IHC (Paraffin sections) (IHC-P). GTX60935

GTX60935 IHC-P Image

Immunohistochemistry (IHC) analyzes of Cox-2 pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Anti-COX2 antibody used in Western Blot (WB). GTX60935

GTX60935 WB Image

Orthogonal

The data was published in the journal Nutrients in 2018. PMID: 30200495

REFERENCE

Application Reference

Ling X et al. Cell Mol Biol Lett 2023; 28 (1) : 91 Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury.
Liu X et al. Open Life Sci 2023; 18 (1) : 20220649 DUSP2 inhibits the progression of lupus nephritis in mice by regulating the STAT3 pathway.
Yan Sun et al. Immun Inflamm Dis 2022; 10 (7) : e641 TRPM7 promotes lipopolysaccharide-induced inflammatory dysfunction in renal tubular epithelial cells.
Application : WB
Reactivity : Human
Hsieh YH et al. Nutrients 2018; 10 (9) Ginsenoside Rh2 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Regulating the TLR4/PI3K/Akt/mTOR, Raf-1/MEK/ERK, and Keap1/Nrf2/HO-1 Signaling Pathways in Mice.
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399