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CRLF2 antibody

Anti-CRLF2 antibody used in Western Blot (WB). GTX85052
Anti-CRLF2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85052
Anti-CRLF2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85052

Cat. No. GTX85052

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human
Package
100 μg ($419)
See all CRLF2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5 - 1 μg/mL
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

42 kDa. ( Note )

Positive Control

Human Liver Tissue Slide , Human Liver Tissue Lysate

Product Note

At least two isoforms are known to exist; this antibody will recognize both isoforms.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

CRLF2 antibody was raised against a 19 amino acid synthetic peptide from near the center of human CRLF2.The immunogen is located within amino acids 140 - 190 of CRLF2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

cytokine receptor like factor 2 , CRL2 , CRLF2Y , TSLPR

Background

Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. Despite its predicted molecular weight, TSLP-R often migrates at a higher molecular weight in SDS-PAGE.

Database

Research Area

DATA IMAGES

Anti-CRLF2 antibody used in Western Blot (WB). GTX85052

GTX85052 WB Image

WB analysis of human liver tissue lysate using GTX85052 CRLF2 antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml

Anti-CRLF2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85052

GTX85052 IHC-P Image

IHC-P analysis of human liver tissue using GTX85052 CRLF2 antibody.
Working concentration : 5 μg/ml

Anti-CRLF2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85052

GTX85052 IHC-P Image

IHC-P analysis of human liver tissue using GTX85052 CRLF2 antibody.
Working concentration : 20 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 419