APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
Assay dependent |
Assay dependent |
Assay dependent |
Not tested in other applications.
Calculated MW
Product Note
This antibody reacts with Csk (C-terminal Src kinase).
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
15mM Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Bacterially expressed recombinant fragment of human Csk corresponding to aa 330-450.
Purification
Protein A purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
CSK , csrc tyrosine kinase , C-terminal Src kinase
Cellular Localization
Cytoplasm,Cell membrane
Background
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
Database
Research Area
DATA IMAGES
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GTX14996 ICC/IF Image
ICC/IF analysis of HeLa cells using GTX14996 CSK antibody [CSK-04]. Green : Primary antibody Red : Actin Blue : DAPI
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REFERENCE
There are currently no references for CSK antibody [CSK-04] (GTX14996). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for CSK antibody [CSK-04] (GTX14996). Be the first to share your experience with this product.