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CTLA4 antibody [BNI3] (Low Endotoxin)

Cat. No. GTX00492-00

Reference 3

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 BNI3

Isotype

 IgG2a

Application

 ICC/IF, IHC-P, IHC-Fr, FACS, IP

Reactivity

 Human
Package
100 μg ($399)
See all CTLA4 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
IHC-P Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

25 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human CD152-IgG heavy chain fusion protein

Purification

Protein A purified

Endotoxin

< 0.01 EU/μg (determined by the LAL assay)

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ALPS5 , CD , CD152 , CELIAC3 , CTLA4 , GRD4 , GSE , IDDM12 , cytotoxic Tlymphocyte associated protein 4 , cytotoxic T-lymphocyte associated protein 4

Cellular Localization

Cell membrane

Background

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Clone Reference

Giorgio Santoni et al. Oncotarget. 2018; 9 (24):16665–16677 High CTLA-4 expression correlates with poor prognosis in thymoma patients
Application : IHC-P
Reactivity : Human
Zhao Y et al. Biomed Pharmacother 2017; 90:147-152 Enhance the anti-renca carcinoma effect of a DNA vaccine targeting G250 gene by co-expression with cytotoxic T-lymphocyte associated antigen-4(CTLA-4).
Nicholas Gulati et al. F1000Res . 2015; 4 (149) Psoriasis is characterized by deficient negative immune regulation compared to transient delayed-type hypersensitivity reactions
Application : IHC-Fr
Reactivity : Human
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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399
Custom Conjugations