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CTLA4 antibody [BNI3] (Low Endotoxin)

Cat No. GTX00492-00

Host

Mouse

Clonality

Monoclonal

Clone Name

BNI3

Isotype

IgG2a

Application

ICC/IF, IHC-Fr, FACS, IP

Reactivity

Human
Package
100 μg ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF Assay dependent
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

25 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 0.2 μm filter sterilized.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human CD152-IgG heavy chain fusion protein

Purification

Protein A purified

Endotoxin

Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

ALPS5,CD,CD152,CELIAC3,CTLA4,GRD4,GSE,IDDM12,cytotoxic Tlymphocyte associated protein 4,cytotoxic T-lymphocyte associated protein 4

Cellular Localization

Cell membrane

Background

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

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REVIEW

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