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CTLA4 antibody [BNI3] (PE-Cy7)

Cat. No. GTX00492-10

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 BNI3

Isotype

 IgG2a

Application

 FACS

Reactivity

 Human
Package
100 test ($319)
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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS 4 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension
Not tested in other applications.

Calculated MW

25 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

15mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human CD152-IgG heavy chain fusion protein

Purification

Purified by size-exclusion chromatography

Conjugation

Phycoerythrin-Cyanine7 (PE-Cy7)

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. Cy and CyDye are trademarks of GE Healthcare.

TARGET

Synonyms

ALPS5 , CD , CD152 , CELIAC3 , CTLA4 , GRD4 , GSE , IDDM12 , cytotoxic Tlymphocyte associated protein 4 , cytotoxic T-lymphocyte associated protein 4

Cellular Localization

Cell membrane

Background

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

Clone Reference

Zhao Y et al. Biomed Pharmacother 2017; 90:147-152 Enhance the anti-renca carcinoma effect of a DNA vaccine targeting G250 gene by co-expression with cytotoxic T-lymphocyte associated antigen-4(CTLA-4).
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 319