PBS, 5% trehalose
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
recombinant human IP-10.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
C-X-C Motif Chemokine Ligand 10,C7,Ifi10,Inp10,Ip-10,Scyb10,Crg-2,Gip-10,Mob-1,Cxcl10
IP-10 is a member of the C-X-C, or alpha chemokine class. It does not contains the ELR domain immediately preceding the first cysteine residue near the amino terminus. Other chemokines in this group include mouse CRG, Mig, PBSF/SDF-1, and PF4. These chemokines act primarily as chemoattractants and activate monocytes, dendritic cells, T lymphocytes, natural killer cells, B lymphocytes, basophils, and eosinophils. IP-10 was originally identified as an IFN-gamma- inducible gene in monocytes, fibroblasts, and endothelial cells. IP-10 is a chemoattractant for activated T lymphocytes. It is a potent inhibitor of angiogenesis and displays a thymus-dependent antitumor effect. IP-10 is an approximately 8.7 kDa polypeptide of 78 amino acids. The precursor form of human IP-10 consists of 98 amino acids. To generate the mature IP-10, the precursor cleaves its 21 amino acid signal peptide. Human IP-10 shows 67% amino acid homology to mouse CRG-2.