CXCR1 antibody [C2C3], C-term

Name: CXCR1 antibody [C2C3], C-term
Brand: GeneTex
SKU: GTX100389
Price: 399.00 USD
Rating: 5 (1 reviews)

Anti-CXCR1 antibody [C2C3], C-term used in IHC (Paraffin sections) (IHC-P). GTX100389

Anti-CXCR1 antibody [C2C3], C-term used in IHC (Frozen sections) (IHC-Fr). GTX100389

Cat. No. GTX100389

Reference 5

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	ICC/IF, IHC-P, IHC-Fr
Reactivity	Human, Mouse
Package	100 μl ($399), 25 μl ($169)

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View product citations for antibody GTX100389 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
ICC/IF	1:100-1:1000
IHC-P	1:100-1:1000
IHC-Fr	Assay dependent

Not tested in other applications.

Calculated MW

40 kDa. ( Note )

Predict Reactivity

Chimpanzee(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.97 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide encompassing a sequence within the Intracellular domain of human CXCR1. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_1240576

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

C-X-C motif chemokine receptor 1 , C-C , C-C-CKR-1 , CD128 , CD181 , CDw128a , CKR-1 , CMKAR1 , IL8R1 , IL8RA , IL8RBA

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq]

Database

Gene ID: 3577 CXCR1
UniProt: P25024 CXCR1

Research Area

DATA IMAGES

GTX100389 IHC-P Image

CXCR1 antibody [C2C3], C-term detects CXCR1 protein at cell membrane by immunohistochemical analysis.
Sample: Paraffin-embedded human esophageal carcinoma.
CXCR1 stained by CXCR1 antibody [C2C3], C-term (GTX100389) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

GTX100389 IHC-P Image

CXCR1 antibody [C2C3], C-term detects IL8RA protein at cytosol on human hepatoma by immunohistochemical analysis.
Sample: Paraffin-embedded hepatoma.
CXCR1 antibody [C2C3], C-term (GTX100389) dilution: 1:500.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

GTX100389 IHC-P Image

CXCR1 antibody [C2C3], C-term detects CXCR1 protein at cell membrane by immunohistochemical analysis.
Sample: Paraffin-embedded human breast carcinoma.
CXCR1 stained by CXCR1 antibody [C2C3], C-term (GTX100389) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

GTX100389 IHC-P Image

The data was published in the journal Nat Commun in 2016.PMID: 27241286

GTX100389 IHC-P Image

The data was published in the journal Nat Commun in 2016.PMID: 27241286

GTX100389 IHC-P Image

The data was published in the journal Nat Commun in 2016.PMID: 27241286

GTX100389 IHC-Fr Image

The data was published in the journal BMC Cancer in 2014. PMID: 25123545

REFERENCE

Application Reference

Gobbo F et al. bioRxiv 2023; GATA1-defective immune-megakaryocytes as possible drivers of idiopathic pulmonary fibrosis.

Maria Zingariello et al. Biomolecules 2022; 12 (2) Resident Self-Tissue of Proinflammatory Cytokines Rather Than Their Systemic Levels Correlates with Development of Myelofibrosis in Gata1^low Mice.

Application : IHC-P

Reactivity : Mouse

Paola Verachi et al. Front Oncol 2022; 12 : 853484 The CXCR1/CXCR2 Inhibitor Reparixin Alters the Development of Myelofibrosis in the Gata1 ^low Mice.

Application : IHC-P

Reactivity : Mouse

Zhang T et al. Nat Commun 2016; 7 : 11674 CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment.

Application : IHC-P

Reactivity : Mouse

Matsumoto M et al. BMC Cancer 2014; 14 : 588 A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity.

Application : IHC-P

Reactivity : Human

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REVIEW