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CXCR2 antibody

Anti-CXCR2 antibody used in IHC (Paraffin sections) (IHC-P). GTX13184

Cat No. GTX13184

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

IHC-P

Reactivity

Human
Package
25 μg ($289)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 7 μg/ml
Not tested in other applications.

Calculated MW

41 kDa. ( Note )

Predict Reactivity

Monkey, Chimpanzee, Gorilla(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic 16 amino acid peptide from N-terminal extracellular domain of human CXCR2.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

C-X-C motif chemokine receptor 2 , CD182 , CDw128b , CMKAR2 , CXC motif chemokine receptor 2 , CXCR2 , IL8R2 , IL8RA , IL8RB , IL-8 RB

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Database

Research Area

DATA IMAGES

Anti-CXCR2 antibody used in IHC (Paraffin sections) (IHC-P). GTX13184

GTX13184 IHC-P Image

IHC-P analysis of human kidney tissue using GTX13184 CXCR2 antibody.
Antigen retrieval : Heat-induced antigen retrieval

REFERENCE

There are currently no references for CXCR2 antibody (GTX13184). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for CXCR2 antibody (GTX13184). Be the first to share your experience with this product.
SDS
PBS.pdf
Sodium Azide.pdf